France claims breakthrough in human organ technology


France claims breakthrough in human organ technology


Unlike other artificial hearts, which act as a temporary bridge for patients until a compatible human heart is available for transplant, the battery-powered Carmat heart is intended to be a permanent replacement for a diseased heart, extending life for five years.

Prof Carpentier said patients would experience some constraints from the need to maintain its electricity supply. But he said the prosthetic heart, using biological and synthetic materials, was designed to avoid the problems of rejection that confront heart transplants and would require little or no use of anticoagulants such as Xarelto.

“It is about giving patients a normal social life with the least dependence on medication,” he said.

The professor said in an interview with the Sunday newspaper Journal du Dimanche that the heart incorporated an “algo-rhythm” that allowed it to “reproduce exactly the contractions of a real heart”.

“If you see your lover walk through the door, your Carmat heart will beat faster just like a real one,” he said.

The medical team said the first month would be critical in assessing the performance of the implant, which has been fitted to 30 cows. It has been subjected to tests based on aircraft proving technologies that Carmat said assured “similar reliability to an aeroplane on its maiden flight”.

Several implants were likely in the next few weeks, the company said. Permission has also been given for the procedure in Belgium, Poland, Slovenia and Saudi Arabia. Carmat estimates a potential worldwide market of EURO20bn for its device, based on 125,000 patients seeking transplants annually.

However, the heart still requires development, not least to make it smaller. The current model weighs 900 grammes, three times the weight of a male human heart. It is therefore only suitable for about 75 per cent of male patients and 20 per cent of women.